Chief Information Security Officers (CISOs) must implement robust incident response strategies to minimize damage and recover quickly from cyber threats. Key strategies include developing a clear, tested incident response plan, forming a cross-functional response team, ensuring real-time threat detection, and maintaining strong communication protocols during a breach. Regular training, threat simulations, and post-incident reviews help improve readiness. By focusing on speed, coordination, and continuous improvement, CISOs can effectively lead their organizations through security incidents while minimizing business impact.